Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma.

doi:10.1038/s41586-021-03704-y

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma.

Nature - 1 Aug 2021

Oliveira Giacomo, Stromhaug Kari, Klaeger Susan, Kula Tomasz, Frederick Dennie T, Le Phuong M, Forman Juliet, Huang Teddy, Li Shuqiang, Zhang Wandi, Xu Qikai, Cieri Nicoletta, Clauser Karl R, Shukla Sachet A, Neuberg Donna, Justesen Sune, MacBeath Gavin, Carr Steven A, Fritsch Edward F, Hacohen Nir, Sade-Feldman Moshe, Livak Kenneth J, Boland Genevieve M, Ott Patrick A, Keskin Derin B, Wu Catherine J

Abstract excerpt

Interactions between T cell receptors (TCRs) and their cognate tumour antigens are central to antitumour immune responses1-3; however, the relationship between phenotypic characteristics and TCR properties is not well elucidated. Here we show, by linking the antigenic specificity of TCRs and the cellular phenotype of melanoma-infiltrating lymphocytes at single-cell resolution, that tumour specificity shapes the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Datasets as Topic

Share to Lymphocytes, Tumor-Infiltrating

Share to Melanoma

Share to Receptors, Antigen, T-Cell

Share to Single-Cell Analysis

Share to Substrate Specificity

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 34290406
DOI: 10.1038/s41586-021-03704-y
PMCID: PMC9187974

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma.PMID 34290406Read ↗

Landscape of helper and regulatory antitumour CD4+ T cells in melanoma.Semantic proximity Read ↗

Evolution and modulation of antigen-specific T cell responses in melanoma patientsSemantic proximity Read ↗

PD-1 expression conditions T cell avidity within an antigen-specific repertoireSemantic proximity Read ↗

Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in MelanomaSemantic proximity Read ↗

Interlesional diversity of T cell receptors in melanoma with immune checkpoints enriched in tissue-resident memory T cellsSemantic proximity Read ↗

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumorsSemantic proximity Read ↗

Low-avidity T cells drive endogenous tumor immunity in mice and humansSemantic proximity Read ↗

Deep sequencing of the T cell Receptor reveals common and reproducible CD8 <sup>+</sup> signatures of response to checkpoint immunotherapySemantic proximity Read ↗

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma.Semantic proximity Read ↗

Multiomics and spatial mapping characterizes human CD8 + T cell states in cancerSemantic proximity Read ↗

Combined TCR Repertoire Profiles and Blood Cell Phenotypes Predict Melanoma Patient Response to Personalized Neoantigen Therapy plus Anti-PD-1.Semantic proximity Read ↗

Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.