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Article

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.

Nature communications - 21 Nov 2016

Bassani-Sternberg Michal, Bräunlein Eva, Klar Richard, Engleitner Thomas, Sinitcyn Pavel, Audehm Stefan, Straub Melanie, Weber Julia, Slotta-Huspenina Julia, Specht Katja, Martignoni Marc E, Werner Angelika, Hein Rüdiger, H Busch Dirk, Peschel Christian, Rad Roland, Cox Jürgen, Mann Matthias, Krackhardt Angela M

Abstract excerpt

Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leucocyte antigens (HLA) on the surface of native tumour tissue has so far not been successful. Using advanced mass spectrometry (MS) analysis, we survey the melanoma-associated immunopeptidome to a depth of 95,500 patient-presented peptides. We thereby discover a large...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27869121
DOI: 10.1038/ncomms13404
PMCID: PMC5121339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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