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Article

Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016

Matsumoto Takuya, Sasaki Naoto, Yamashita Tomoya, Emoto Takuo, Kasahara Kazuyuki, Mizoguchi Taiji, Hayashi Tomohiro, Yodoi Keiko, Kitano Naoki, Saito Takashi, Yamaguchi Tomoyuki, Hirata Ken-Ichi

Abstract excerpt

OBJECTIVE: Although T-cell-mediated chronic inflammation contributes to atherosclerosis development, the role of a negative regulatory molecule cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) in atherosclerosis is poorly understood. We investigated the effects of CTLA-4 overexpression on atherosclerosis in apolipoprotein E-deficient (Apoe(-/-)) mice. APPROACH AND RESULTS: We generated CTLA-4 transgenic...

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Identifiers

PMID: 27055906
DOI: 10.1161/ATVBAHA.115.306848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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