Article
Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2006
Hadrup Sine Reker, Strindhall Jan, Køllgaard Tania, Seremet Tina, Johansson Boo, Pawelec Graham, thor Straten Per, Wikby Anders
Abstract excerpt
The age-associated decrease in functionality of the human immune system is thought to have a negative impact on the capacity to provide protection against infection, in turn leading to increased incidence of mortality. In a previous longitudinal study of octogenarians, we identified an immune ris...
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