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Cytomegalovirus Exposure in the Elderly Does Not Reduce CD8 T Cell Repertoire Diversity

12 Dec 2018

Abstract excerpt

Abstract With age, the immune system becomes less effective, causing increased susceptibility to infection. Chronic CMV infection further impairs immune function and is associated with increased mortality in the elderly. CMV exposure elicits massive CD8+ T cell clonal expansions and diminishes the cytotoxic T cell response to subsequent infections, leading to the hypothesis that to maintain homeostasis, T cell...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 30541882
DOI: 10.4049/jimmunol.1800217

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