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Article

Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2002

Khan Naeem, Shariff Naseer, Cobbold Mark, Bruton Rachel, Ainsworth Jenni A, Sinclair Alan J, Nayak Laxman, Moss Paul A H

Abstract excerpt

The deterioration in immune function with aging is thought to make a major contribution to the increased morbidity and mortality from infectious disease in old age. One aspect of immune senescence is the reduction in CD8 T cell repertoire as due to the accumulation of oligoclonal, memory T cells and a reduction in the naive T cell pool. CD8 T cell clonal expansions accumulate with age, but their antigenic...

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Share to Antibodies, Viral
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytomegalovirus

Share to Cytomegalovirus Infections

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Share to Oligopeptides

Share to T-Lymphocytes, Cytotoxic

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Source

Identifiers

PMID: 12165524
DOI: 10.4049/jimmunol.169.4.1984

Genes

CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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