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Article

Exonic transcription factor binding directs codon choice and affects protein evolution.

Science (New York, N.Y.) - 13 Dec 2013

Stergachis Andrew B, Haugen Eric, Shafer Anthony, Fu Wenqing, Vernot Benjamin, Reynolds Alex, Raubitschek Anthony, Ziegler Steven, LeProust Emily M, Akey Joshua M, Stamatoyannopoulos John A

Abstract excerpt

Genomes contain both a genetic code specifying amino acids and a regulatory code specifying transcription factor (TF) recognition sequences. We used genomic deoxyribonuclease I footprinting to map nucleotide resolution TF occupancy across the human exome in 81 diverse cell types. We found that ~1...

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Identifiers

PMID: 24337295
DOI: 10.1126/science.1243490
PMCID: PMC3967546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24337295-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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