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Article

Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry.

Molecular bioSystems - 4 Mar 2014

Leney Aneika C, Pashley Clare L, Scarff Charlotte A, Radford Sheena E, Ashcroft Alison E

Abstract excerpt

In vivo beta-2 microglobulin (β2m) forms amyloid fibrils that are associated with the disease dialysis-related amyloidosis. Here, electrospray ionisation-ion mobility spectrometry-mass spectrometry has been used to compare the oligomers formed from wild-type β2m with those formed from a variant of the protein containing a single point mutation in the D strand, H51A, during in vitro fibril assembly. Using the...

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Identifiers

PMID: 24336936
DOI: 10.1039/c3mb70420c
PMCID: PMC4006425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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