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Article

A Self-Consistent Molecular Mechanism of β2-Microglobulin Aggregation.

The journal of physical chemistry. B - 19 Dec 2024

Tammara Vaishnavi, Das Atanu

Abstract excerpt

Despite the consensus on the origin of dialysis-related amyloidosis (DRA) being β2-microglobulin (β2m) aggregation, the debate on the underlying mechanism persists because of the continuous emergence of β2m variant- and pH-dependent contradictory results. By characterizing the native monomeric (initiation) and aggregated fibrillar (termination) states of β2m via a combination of two enhanced sampling approaches,...

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PMID: 39656191
DOI: 10.1021/acs.jpcb.4c06611

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