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Article

Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation.

Biochemical and biophysical research communications - 13 Mar 2009

Ricagno Stefano, Raimondi Sara, Giorgetti Sofia, Bellotti Vittorio, Bolognesi Martino

Abstract excerpt

Beta-2 microglobulin (?2m) is the light chain of class I major histocompatibility complex (MHC-I). Beta2m is an intrinsically amyloidogenic protein that can assemble into amyloid fibrils in a concentration dependent manner. Beta2m is accumulated in serum of haemodialysed patients, and deposited in the skeletal joints, causing dialysis related amyloidosis. Recent reports suggested that the loop comprised between...

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Identifiers

PMID: 19284997
DOI: 10.1016/j.bbrc.2009.01.116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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