Article
Zinc is a potent and specific inhibitor of IFN-λ3 signalling.
Nature communications - 17 May 2017
Read Scott A, O'Connor Kate S, Suppiah Vijay, Ahlenstiel Chantelle L E, Obeid Stephanie, Cook Kristina M, Cunningham Anthony, Douglas Mark W, Hogg Philip J, Booth David, George Jacob, Ahlenstiel Golo
Abstract excerpt
Lambda interferons (IFNL, IFN-λ) are pro-inflammatory cytokines important in acute and chronic viral infection. Single-nucleotide polymorphisms rs12979860 and rs8099917 within the IFNL gene locus predict hepatitis C virus (HCV) clearance, as well as inflammation and fibrosis progression in viral and non-viral liver disease. The underlying mechanism, however, is not defined. Here we show that the rs12979860 CC...
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