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Article

Genetic interaction between two insulin-dependent diabetes susceptibility loci, Idd2 and Idd13, in determining immunoregulatory DN T cell proportion.

Immunogenetics - 1 Aug 2018

Collin Roxanne, Doyon Kathy, Mullins-Dansereau Victor, Karam Martin, Chabot-Roy Geneviève, Hillhouse Erin E, Orthwein Alexandre, Lesage Sylvie

Abstract excerpt

Several immune regulatory cell types participate in the protection against autoimmune diseases such as autoimmune diabetes. Of these immunoregulatory cells, we and others have shown that peripheral CD4-CD8- double negative (DN) T cells can induce antigen-specific immune tolerance. Particularly, we have described that diabetes-prone mice exhibit a lower number of peripheral DN T cells compared to...

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Share to Antigens, Differentiation, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epistasis, Genetic

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Share to T-Lymphocytes, Regulatory

Source

Identifiers

PMID: 29696366
DOI: 10.1007/s00251-018-1060-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic interaction between two insulin-dependent diabetes susceptibility loci, Idd2 and Idd13, in determining immunoregulatory DN T cell proportion.PMID 29696366Read ↗

Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice.Semantic proximity Read ↗

Two genetic loci regulate T cell-dependent islet inflammation and drive autoimmune diabetes pathogenesis.Semantic proximity Read ↗

The idd4 locus displays sex-specific epistatic effects on type 1 diabetes susceptibility in nonobese diabetic mice.Semantic proximity Read ↗

Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC.Semantic proximity Read ↗

Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.Semantic proximity Read ↗

The Idd2 Locus Confers Prominent Resistance to Autoimmune Diabetes.Semantic proximity Read ↗

Evidence of genetic epistasis in autoimmune diabetes susceptibility revealed by mouse congenic sublines.Semantic proximity Read ↗

A locus on mouse chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells.Semantic proximity Read ↗

The Idd13 congenic interval defines the number of merocytic dendritic cells, a novel trait associated with autoimmune diabetes susceptibility.Semantic proximity Read ↗

Genome-wide transcriptional analyses of islet-specific CD4+ T cells identify Idd9 genes controlling diabetogenic T cell function.Semantic proximity Read ↗

The enlarged population of marginal zone/CD1d(high) B lymphocytes in nonobese diabetic mice maps to diabetes susceptibility region Idd11.Semantic proximity Read ↗

Subcongenic analysis of the Idd13 locus in NOD/Lt mice: evidence for several susceptibility genes including a possible diabetogenic role for beta 2-microglobulin.Semantic proximity Read ↗

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