Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2013

Clark Simon J, Ridge Liam A, Herbert Andrew P, Hakobyan Svetlana, Mulloy Barbara, Lennon Rachel, Würzner Reinhard, Morgan B Paul, Uhrín Dusan, Bishop Paul N, Day Anthony J

Abstract excerpt

Complement factor H (CFH) regulates complement activation in host tissues through its recognition of polyanions, which mediate CFH binding to host cell surfaces and extracellular matrix, promoting the deactivation of deposited C3b. These polyanions include heparan sulfate (HS), a glycosaminoglycan with a highly diverse range of structures, for which two regions of CFH (CCP6-8 and CCP19-20) have been implicated in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atypical Hemolytic Uremic Syndrome
Share to Autopsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Activation

Share to Complement Factor H

Share to Hemolytic-Uremic Syndrome

Share to Heparitin Sulfate

Share to Macular Degeneration

Source

Open in PubMed Open full text

Identifiers

PMID: 23365078
DOI: 10.4049/jimmunol.1201751
PMCID: PMC3672945

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.PMID 23365078Read ↗

The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?Semantic proximity Read ↗

Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.Semantic proximity Read ↗

His-384 allotypic variant of factor H associated with age-related macular degeneration has different heparin binding properties from the non-disease-associated form.Semantic proximity Read ↗

Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.Semantic proximity Read ↗

Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular DegenerationSemantic proximity Read ↗

Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.Semantic proximity Read ↗

Translational mini-review series on complement factor H: structural and functional correlations for factor H.Semantic proximity Read ↗

The human complement factor H: functional roles, genetic variations and disease associations.Semantic proximity Read ↗

Revisiting the role of factor H in age-related macular degeneration: Insights from complement-mediated renal disease and rare genetic variants.Semantic proximity Read ↗

Selective Binding of Heparin/Heparan Sulfate Oligosaccharides to Factor H and Factor H-Related Proteins: Therapeutic Potential for C3 GlomerulopathiesSemantic proximity Read ↗

Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro.Semantic proximity Read ↗

Functional Anatomy of Complement Factor HSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.