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Article

Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

The Journal of biological chemistry - 24 Sept 2010

Clark Simon J, Perveen Rahat, Hakobyan Svetlana, Morgan B Paul, Sim Robert B, Bishop Paul N, Day Anthony J

Abstract excerpt

Age-related macular degeneration (AMD) is the predominant cause of blindness in the industrialized world where destruction of the macula, i.e. the central region of the retina, results in loss of vision. AMD is preceded by the formation of deposits in the macula, which accumulate between the Bruch's membrane and the retinal pigment epithelium (RPE). These deposits are associated with complement-mediated...

Topics

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Amino Acid Substitution
Complement Activation
Complement Factor H
Heparitin Sulfate
Macula Lutea

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Macular Degeneration

Mutation, Missense

Retinal Pigment Epithelium

Source

Open in PubMed Open full text

Identifiers

PMID: 20660596
DOI: 10.1074/jbc.M110.103986
PMCID: PMC2943316

Genes

CFH
RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.PMID 20660596Read ↗

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Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular DegenerationSemantic proximity Read ↗

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Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular DegenerationSemantic proximity Read ↗

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