Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.

Biochemical Society transactions - 1 Oct 2010

Clark Simon J, Bishop Paul N, Day Anthony J

Abstract excerpt

AMD (age-related macular degeneration) is the major cause of blindness in the western world, associated with the formation of extracellular deposits called drusen in the macula, i.e. the central region of the retina. These drusen contain cellular debris and proteins, including components of the complement system such as the regulator CFH (complement factor H); dysregulation of complement is thought to play a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement Factor H
Share to CFH gene
Share to Glycosaminoglycans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macular Degeneration

Share to Models, Biological

Share to Polymorphism, Single Nucleotide

Share to Protein Binding

Source

Identifiers

PMID: 20863311
DOI: 10.1042/BST0381342

Genes

CFH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.PMID 20863311Read ↗

Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.Semantic proximity Read ↗

Complement factor H in AMD: Bridging genetic associations and pathobiology.Semantic proximity Read ↗

The role of complement in age-related macular degeneration: heparan sulphate, a ZIP code for complement factor H?Semantic proximity Read ↗

Role of Factor H and Related Proteins in Regulating Complement Activation in the Macula, and Relevance to Age-Related Macular DegenerationSemantic proximity Read ↗

The role of complement in AMD.Semantic proximity Read ↗

Complement factor H Y402H polymorphism results in diminishing CD4+ T cells and increasing C-reactive protein in plasma.Semantic proximity Read ↗

Analysis of the Y402H variant of the complement factor H gene in age-related macular degeneration.Semantic proximity Read ↗

Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular DegenerationSemantic proximity Read ↗

Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in miceSemantic proximity Read ↗

Age-related macular degeneration: Complement in action.Semantic proximity Read ↗

Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.Semantic proximity Read ↗

Functional and structural implications of the complement factor H Y402H polymorphism associated with age-related macular degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.