Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.

doi:10.1097/00008571-200104000-00004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.

Pharmacogenetics - 1 Apr 2001

Fretland A J, Leff M A, Doll M A, Hein D W

Abstract excerpt

N-Acetyltransferase 2 (NAT2) catalyses the activation and/or deactivation of a variety of aromatic amine drugs and carcinogens. Polymorphisms in the N-acetyltransferase 2 (NAT2) gene have been associated with a variety of drug-induced toxicities, as well as cancer in various tissues. Eleven single nucleotide polymorphisms (SNPs) have been identified in the NAT2 coding region, but the specific effects of each of...

Topics

Arylamine N-Acetyltransferase
Blotting, Northern
Blotting, Southern
Blotting, Western
Gene Expression
Humans
Microbial Sensitivity Tests
Polymorphism, Single Nucleotide
Recombinant Proteins
Schizosaccharomyces
Structure-Activity Relationship
Substrate Specificity
Sulfamethazine

Source

Open in PubMed

Identifiers

PMID: 11337936
DOI: 10.1097/00008571-200104000-00004

Genes

NAT2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics