Article

Mesenchymal stromal cells release CXCL1/2/8 and induce chemoresistance and macrophage polarization

2018-12-04

Abstract excerpt

Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells (CA-MSCs) are involved in tumor progression and chemoresistance. We determine the mechanisms by which a naïve MSC could become a CA-MSC and characterize CA-MSCs. Ovarian tumor cells (OTC) trigger the transformation of MSCs to CA-MSCs expressing different pro-tumoral, genes and secreting high amounts of CXCR1/2 ligands (CXCL1,...

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Literature Corpus work: f98000a0-293f-5da3-9523-3c1effef2110
DOI: 10.1101/482513

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