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Article

Analysis of induced pluripotent stem cells from a BRCA1 mutant family.

Stem cell reports - 1 Jan 2013

Soyombo Abigail A, Wu Yipin, Kolski Lauren, Rios Jonathan J, Rakheja Dinesh, Chen Alice, Kehler James, Hampel Heather, Coughran Alanna, Ross Theodora S

Abstract excerpt

Understanding BRCA1 mutant cancers is hampered by difficulties in obtaining primary cells from patients. We therefore generated and characterized 24 induced pluripotent stem cell (iPSC) lines from fibroblasts of eight individuals from a BRCA1 5382insC mutant family. All BRCA1 5382insC heterozygous fibroblasts, iPSCs, and teratomas maintained equivalent expression of both wild-type and mutant BRCA1 transcripts....

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Source

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Identifiers

PMID: 24319668
DOI: 10.1016/j.stemcr.2013.08.004
PMCID: PMC3849250

Genes

BRCA1

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