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Generation of two induced pluripotent stem cell lines from breast cancer patients carrying BRCA1 mutations.

Stem cell research - 1 Aug 2025

Chen Yi-Ing, Caudal Arianne, Flores-Banuelos Amira G, Yan Christopher D, Park Walter G, Viswanathan Mohan, Wu Joseph C

Abstract excerpt

Haploinsufficiency of BRCA1 increases the risk of various cancers due to its critical functions in cell cycle checkpoint regulation and DNA repair. This study generated and characterized two induced pluripotent stem cell (iPSC) lines derived from breast cancer patients with mutations in the BRCA1 gene (c.676del and c.5096G>A). Both lines exhibited typical iPSC morphology, karyotype, pluripotency marker...

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Identifiers

PMID: 40286603
DOI: 10.1016/j.scr.2025.103716
PMCID: PMC12203875

Genes

BRCA1

Variants

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