Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by BRCA1 mutation.

doi:10.1126/sciadv.adi2370

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Article

Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by BRCA1 mutation.

Science advances - 25 Jul 2025

Liu Jingxin, Zhao Cai, Chen Jiahao, Zeng Pengguihang, Li Qingjian, Dai Ranran, Lai Xingqiang, Song Wenqian, Chen Jianing, Zhu Xixi, Liu Xinyi, Sun Jun, Wang Jia, Fang Peihang, Wang Tengfei, Chen Wenjie, Guallar Diana, Cao Nan, Zhao Jianli, Su Shicheng, Xiang Andy Peng, Zeng Yi Arial, Li Jie, Cai Junchao, Lee Dung-Fang, Bei Jinxin, Huo Yongliang, Hu Hai, Suo Shengbao, Huang Dong-Feng, Bai Jin, Ding Junjun

Abstract excerpt

Breast cancer is the most common malignancy in females and remains the leading cause of cancer-related deaths for women worldwide. The cellular and molecular basis of breast tumorigenesis is not completely understood partly due to the lack of human research models which simulate the development of breast cancer. Here, we developed a method for generating functional mammary-like cells (MCs) from human-induced...

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Identifiers

PMID: 40712032
DOI: 10.1126/sciadv.adi2370
PMCID: PMC12292934

Genes

BRCA1
S100P

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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