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Generation and characterization of induced pluripotent stem cells from a family carrying the BRCA1 mutation c.3612delA.

Stem cell research - 1 Apr 2021

Silva Teresa P, Pereira Carolina A, Oliveira Ana Rita, Raposo Ana Cláudia, Arez Maria, Cabral Joaquim M S, Milagre Inês, Carmo-Fonseca Maria, da Rocha Simão T

Abstract excerpt

How BRCA1 germline mutations predispose to cancer remains poorly understood. Induced pluripotent stem cells (iPSCs) represent an emerging model to investigate the molecular mechanisms underlying malignant transformation in primary cells from individuals who are carriers of deleterious mutations in the BRCA1 gene. Here we report the generation and characterization of iPSC lines from a female donor harboring a...

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PMID: 33631522
DOI: 10.1016/j.scr.2021.102242

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