Article
The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2014
Su Wei, Hopkins Stephanie, Nesser Nicole K, Sopher Bryce, Silvestroni Aurelio, Ammanuel Simon, Jayadev Suman, Möller Thomas, Weinstein Jonathan, Garden Gwenn A
Abstract excerpt
Neuroinflammation occurs in acute and chronic CNS injury, including stroke, traumatic brain injury, and neurodegenerative diseases. Microglia are specialized resident myeloid cells that mediate CNS innate immune responses. Disease-relevant stimuli, such as reactive oxygen species (ROS), can influ...
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