Article
MafB antagonizes phenotypic alteration induced by GM-CSF in microglia.
Biochemical and biophysical research communications - 1 Jan 2000
Koshida Ryusuke, Oishi Hisashi, Hamada Michito, Takahashi Satoru
Abstract excerpt
Microglia are tissue-resident macrophages which are distributed throughout the central nervous system (CNS). Recent studies suggest that microglia are a unique myeloid population distinct from peripheral macrophages in terms of origin and gene expression signature. Granulocyte-macrophage colony-stimulating factor (GM-CSF), a pleiotropic cytokine regulating myeloid development, has been shown to stimulate...
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