Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia.

PloS one - 1 Jan 2013

Freilich Robert W, Woodbury Maya E, Ikezu Tsuneya

Abstract excerpt

Neuroinflammation contributes to many neurologic disorders including Alzheimer's disease, multiple sclerosis, and stroke. Microglia is brain resident myeloid cells and have emerged as a key driver of the neuroinflammatory responses. MicroRNAs (miRNAs) provide a novel layer of gene regulation and play a critical role in regulating the inflammatory response of peripheral macrophages. However, little is known about...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cluster Analysis
Share to Interleukin-4
Share to Lipopolysaccharides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microglia

Share to MicroRNAs

Share to Reproducibility of Results

Share to RNA Interference

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 24244499
DOI: 10.1371/journal.pone.0079416
PMCID: PMC3823621

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia.PMID 24244499Read ↗

The transcriptional landscape of human microglia reveals strong conservation of miRNAs and preservation of function across vertebrate speciesSemantic proximity Read ↗

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization.Semantic proximity Read ↗

Identifying functional microRNAs in macrophages with polarized phenotypes.Semantic proximity Read ↗

Next-generation sequencing of microRNAs uncovers expression signatures in polarized macrophages.Semantic proximity Read ↗

Mouse microglia express unique miRNA-mRNA networks to facilitate age-specific functions in the developing central nervous systemSemantic proximity Read ↗

Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brainSemantic proximity Read ↗

MicroRNAs in immune response and macrophage polarization.Semantic proximity Read ↗

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1Semantic proximity Read ↗

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signaturesSemantic proximity Read ↗

Dynamic macrophage polarization-specific miRNA patterns reveal increased soluble VEGF receptor 1 by miR-125a-5p inhibition.Semantic proximity Read ↗

lncRNA <i>3222401L13Rik</i> / <i>ENSG00000272070</i> modulates microglial inflammatory programs in association with PU.1Semantic proximity Read ↗

Interfering PTBP1 expression inducing M2 macrophage polarization via miR-124/MAPK pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.