Article
Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction.
Clinical & experimental metastasis - 1 Sept 1997
Chen Z, Smith C W, Kiel D, Van Waes C
Abstract excerpt
The purpose of this study was to develop an experimental model of squamous cell carcinoma that can be used to identify molecular and immunologic changes associated with primary events in malignant transformation, and those associated with metastatic tumor progression in the presence of host homeostatic and immunologic factors. Metastatic variants were derived following in vivo tumor progression of the in vitro...
Topics
- Animals
- Carcinoma, Squamous Cell
- Cell Differentiation
- Cell Division
- Cell Line, Transformed
- Disease Models, Animal
- Epithelium
- Lung Neoplasms
- Lymph Nodes
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Phenotype