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Article

Evidence for nutrient modulation of tumor phenotype: impact of tyrosine and phenylalanine restriction.

Advances in experimental medicine and biology - 1 Jan 1994

Elstad C A, Meadows G G, Aslakson C J, Starkey J R

Abstract excerpt

We have shown that Tyr and Phe restriction suppresses the malignant phenotype of the highly invasive and metastatic BL6 variant of B16 murine melanoma. Lung-colonizing abilities of Tyr- and Phe-modulated in vivo and in vitro variants of BL6 are inhibited following intravenous inoculation into mice fed normal diet. Although this antimetastatic effect of Tyr and Phe restriction is most likely not due to differences...

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PMID: 7520663
DOI: 10.1007/978-1-4899-0939-8_13

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 9 closest

Evidence for nutrient modulation of tumor phenotype: impact of tyrosine and phenylalanine restriction.PMID 7520663Read ↗

Modulation of B16-BL6 murine melanoma metastatic phenotype by tyrosine and phenylalanine restriction in the absence of host selection pressures.Semantic proximity Read ↗

Specificity of the suppression of metastatic phenotype by tyrosine and phenylalanine restriction.Semantic proximity Read ↗

Phenotypic stability of B16-BL6 melanoma exposed to low levels of tyrosine and phenylalanine.Semantic proximity Read ↗

Metastatic variants of the B16 melanoma: metastasis is related to environmental conditions. Phenotypic changes in vitro and metastatic colonization potential in nude mice.Semantic proximity Read ↗

In vitro modulation of the metastatic phenotype. I. Analysis of differentiation forms of the B16 melanoma expressing Met-72 determinants and metastatic activity.Semantic proximity Read ↗

Inhibition by Tyroserleutide (YSL) on the Invasion and Adhesion of the Mouse Melanoma CellSemantic proximity Read ↗

The modulation of B16BL6 melanoma metastasis is not directly mediated by cytolytic activity of natural killer cells in alcohol-consuming mice.Semantic proximity Read ↗

Diverse manifestations of tumorigenicity and immunogenicity displayed by the poorly immunogenic B16-BL6 melanoma transduced with cytokine genes.Semantic proximity Read ↗

Overexpression of normal c-Src in poorly metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential.Semantic proximity Read ↗

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