Evidence for nutrient modulation of tumor phenotype: impact of tyrosine and phenylalanine restriction.

doi:10.1007/978-1-4899-0939-8_13

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Article

Evidence for nutrient modulation of tumor phenotype: impact of tyrosine and phenylalanine restriction.

Advances in experimental medicine and biology - 1 Jan 1994

Elstad C A, Meadows G G, Aslakson C J, Starkey J R

Abstract excerpt

We have shown that Tyr and Phe restriction suppresses the malignant phenotype of the highly invasive and metastatic BL6 variant of B16 murine melanoma. Lung-colonizing abilities of Tyr- and Phe-modulated in vivo and in vitro variants of BL6 are inhibited following intravenous inoculation into mic...

Topics

Animal Nutritional Physiological Phenomena
Animals
Diet
Female
Killer Cells, Natural
Lung
Mast Cells
Melanoma, Experimental
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasm Metastasis
Neoplasm Transplantation
Neovascularization, Pathologic
Phenotype
Phenylalanine
Tumor Cells, Cultured
Tyrosine

Source

Open in PubMed

Identifiers

PMID: 7520663
DOI: 10.1007/978-1-4899-0939-8_13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7520663-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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