Article
Lack of phospholipase A2 receptor increases susceptibility to cardiac rupture after myocardial infarction.
Circulation research - 31 Jan 2014
Mishina Hideto, Watanabe Kazuhiro, Tamaru Shun, Watanabe Yosuke, Fujioka Daisuke, Takahashi Soichiro, Suzuki Koji, Nakamura Takamitsu, Obata Jun-Ei, Kawabata Kenichi, Yokota Yasunori, Inoue Osamu, Murakami Makoto, Hanasaki Kohji, Kugiyama Kiyotaka
Abstract excerpt
RATIONALE: Recent evidence indicates that the biological effects of secretory phospholipase A2 (sPLA2) cannot be fully explained by its catalytic activity. A cell surface receptor for sPLA2 (PLA2 receptor 1 [PLA2R]) and its high-affinity ligands (including sPLA2-IB, sPLA2-IIE, and sPLA2-X) are expressed in the infarcted myocardium. OBJECTIVE: This study asked whether PLA2R might play a pathogenic role in...
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