Article
Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver.
Journal of the American Heart Association - 13 Nov 2015
Hernandez-Anzaldo Samuel, Berry Evan, Brglez Vesna, Leung Dickson, Yun Tae Jin, Lee Jun Seong, Filep Janos G, Kassiri Zamaneh, Cheong Cheolho, Lambeau Gérard, Lehner Richard, Fernandez-Patron Carlos
Abstract excerpt
BACKGROUND: Endocrine functions of the heart have been well established. We investigated the hypothesis that cardiac secretion of a unique phospholipase A2 recently identified by our laboratory (cardiac secreted phospholipase A2 [sPLA2]) establishes a heart-liver endocrine axis that is negatively regulated by matrix metalloproteinase-2 (MMP-2). METHODS AND RESULTS: In Mmp2(-/-) mice, cardiac (but not hepatic)...
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