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Article

Secreted Phospholipase A2-IIA Modulates Transdifferentiation of Cardiac Fibroblast through EGFR Transactivation: An Inflammation-Fibrosis Link.

Cells - 8 Feb 2020

Martin Ruben, Gutierrez Beatriz, Cordova Claudia, Roman Alberto San, Alvarez Yolanda, Hernandez Marita, Cachofeiro Victoria, Nieto Maria L

Abstract excerpt

Secreted phospholipase A2-IIA (sPLA2-IIA) is a pro-inflammatory protein associated with cardiovascular disorders, whose functions and underlying mechanisms in cardiac remodelling are still under investigation. We herein study the role of sPLA2-IIA in cardiac fibroblast (CFs)-to-myofibroblast differentiation and fibrosis, two major features involved in cardiac remodelling, and also explore potential mechanisms...

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PMID: 32046347
DOI: 10.3390/cells9020396
PMCID: PMC7072256

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