Article
Planar cell polarity acts through septins to control collective cell movement and ciliogenesis.
Science (New York, N.Y.) - 10 Sept 2010
Kim Su Kyoung, Shindo Asako, Park Tae Joo, Oh Edwin C, Ghosh Srimoyee, Gray Ryan S, Lewis Richard A, Johnson Colin A, Attie-Bittach Tania, Katsanis Nicholas, Wallingford John B
Abstract excerpt
The planar cell polarity (PCP) signaling pathway governs collective cell movements during vertebrate embryogenesis, and certain PCP proteins are also implicated in the assembly of cilia. The septins are cytoskeletal proteins controlling behaviors such as cell division and migration. Here, we identified control of septin localization by the PCP protein Fritz as a crucial control point for both collective cell...
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