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Article

Relative resistance of HIV-1 founder viruses to control by interferon-alpha

1 Dec 2013

Abstract excerpt

BACKGROUND: Following mucosal human immunodeficiency virus type 1 (HIV-1) transmission, type 1 interferons (IFNs) are rapidly induced at sites of initial virus replication in the mucosa and draining lymph nodes. However, the role played by IFN-stimulated antiviral activity in restricting HIV-1 replication during the initial stages of infection is not clear. We hypothesized that if type 1 IFNs exert selective...

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PMID: 24299076
DOI: 10.1186/1742-4690-10-146

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