Article
Reduced HIV-1 long terminal repeat transcription in subjects with protective interferon regulatory factor-1 genotype: a potential mechanism mediating resistance to infection by HIV-1.
Scandinavian journal of infectious diseases - 1 May 2010
Ji Hezhao, Ball Terry Blake, Ao Zhujun, Kimani Joshua, Yao Xiaojian, Plummer Francis Allan
Abstract excerpt
We previously described the polymorphism in the interferon regulatory factor-1 (IRF-1) gene as a novel correlate of resistance to HIV-1 infection in a Kenyan female sex worker cohort. However, the underlying mechanisms likely mediating this association remained to be elucidated. The initiation of HIV-1 long terminal repeat (LTR) transcription in peripheral blood mononuclear cells (PBMCs) from subjects with...
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