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Article

Adaptation to the Interferon-Induced Antiviral State by Human and Simian Immunodeficiency Viruses

17 Jan 2013

Abstract excerpt

The production of type I interferon (IFN) is an early host response to different infectious agents leading to the induction of hundreds of IFN-stimulated genes (ISGs). The roles of many ISGs in host defense are unknown, but their expression results in the induction of an "antiviral state" that inhibits the replication of many viruses. Here we show that prototype primate lentiviruses human immunodeficiency virus...

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PMID: 23325684
DOI: 10.1128/jvi.03219-12

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