Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Macaque lymphocytes transduced by a constitutively expressed interferon beta gene display an enhanced resistance to SIVmac251 infection.

Human gene therapy - 10 Feb 1999

Matheux F, Le Grand R, Rousseau V, De Maeyer E, Dormont D, Lauret E

Abstract excerpt

We are developing a method of gene therapy of HIV infection based on the low constitutive expression of an interferon beta (IFN-beta) gene in HIV target cells. Herein we report the first step in the development of a relevant animal model, provided by the macaque (Macaca fascicularis) infected with a pathogenic SIVmac251 isolate. To avoid the possibility of in vivo rejection of macaque lymphocytes expressing Hu...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3 Cells
Share to Immunity, Cellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-beta

Share to Macaca fascicularis

Share to Retroviridae

Share to Simian Acquired Immunodeficiency Syndrome

Share to Simian Immunodeficiency Virus

Share to Transduction, Genetic

Source

Identifiers

PMID: 10048395
DOI: 10.1089/10430349950018878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Macaque lymphocytes transduced by a constitutively expressed interferon beta gene display an enhanced resistance to SIVmac251 infection.PMID 10048395Read ↗

Adaptation to the Interferon-Induced Antiviral State by Human and Simian Immunodeficiency VirusesSemantic proximity Read ↗

Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer.Semantic proximity Read ↗

Macrophage tropism of human immunodeficiency virus type 1 facilitates in vivo escape from cytotoxic T-lymphocyte pressure.Semantic proximity Read ↗

Relative resistance of HIV-1 founder viruses to control by interferon-alphaSemantic proximity Read ↗

Partial Inhibition of Human Immunodeficiency Virus Replication by Type I Interferons: Impact of Cell-to-Cell Viral TransferSemantic proximity Read ↗

Protection of stem cell-derived lymphocytes in a primate AIDS gene therapy model after in vivo selection.Semantic proximity Read ↗

Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cellsSemantic proximity Read ↗

Human MxA Protein Protects Mice Lacking a Functional Alpha/Beta Interferon System against La Crosse Virus and Other Lethal Viral InfectionsSemantic proximity Read ↗

A dominant block to HIV-1 replication at reverse transcription in simian cellsSemantic proximity Read ↗

Antiretroviral Therapy during Primary Immunodeficiency Virus Infection Can Induce Persistent Suppression of Virus Load and Protection from Heterologous Challenge in Rhesus MacaquesSemantic proximity Read ↗

A Rev-inducible mutant gag gene stably transferred into T lymphocytes: an approach to gene therapy against human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

Rmcf2, a xenotropic provirus in the Asian mouse species Mus castaneus, blocks infection by polytropic mouse gammaretroviruses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.