Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alpha interferon inhibits early stages of the human immunodeficiency virus type 1 replication cycle

1 Mar 1992

Abstract excerpt

In this study, we have analyzed the effect of human alpha interferon (IFN-alpha) on a single replication cycle of human immunodeficiency virus type 1 (HIV-1) infection in the lymphocytic cell line CEM-174, which is highly sensitive to the antiviral effects of IFN. Pretreatment of cells with 50 to 500 U of recombinant human IFN-alpha per ml resulted in a marked reduction in viral RNA and protein synthesis. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1738192
DOI: 10.1128/jvi.66.3.1321-1328.1992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alpha interferon inhibits early stages of the human immunodeficiency virus type 1 replication cyclePMID 1738192Read ↗

Characterization of the Alpha Interferon-Induced Postentry Block to HIV-1 Infection in Primary Human Macrophages and T CellsSemantic proximity Read ↗

Type I and Type II Interferons Inhibit the Translation of Murine Norovirus ProteinsSemantic proximity Read ↗

Multiple effects of interferon on the replication of human immunodeficiency virus type 1Semantic proximity Read ↗

Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factorSemantic proximity Read ↗

Early events in alphavirus replication determine the outcome of infection.Semantic proximity Read ↗

Effects of Alpha Interferon Treatment on Intrinsic Anti-HIV-1 Immunity In VivoSemantic proximity Read ↗

Partial Inhibition of Human Immunodeficiency Virus Replication by Type I Interferons: Impact of Cell-to-Cell Viral TransferSemantic proximity Read ↗

Simultaneous RNA quantification of human and retroviral genomes reveals intact interferon signaling in HTLV-1-infected CD4+ T cell linesSemantic proximity Read ↗

Long‐term survival and virus production in human primary macrophages infected by human immunodeficiency virusSemantic proximity Read ↗

Activation of cellular interferon-responsive genes after infection of human cells with herpes simplex virus type 1Semantic proximity Read ↗

Mouse cytomegalovirus inhibits beta interferon (IFN-β) gene expression and controls activation pathways of the IFN-β enhanceosomeSemantic proximity Read ↗

Human immunodeficiency virus type 1 RNA expression by four chronically infected cell lines indicates multiple mechanisms of latencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.