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Article

Overexpression of KCNN3 results in sudden cardiac death.

Cardiovascular research - 1 Feb 2014

Mahida Saagar, Mills Robert W, Tucker Nathan R, Simonson Bridget, Macri Vincenzo, Lemoine Marc D, Das Saumya, Milan David J, Ellinor Patrick T

Abstract excerpt

BACKGROUND: A recent genome-wide association study identified a susceptibility locus for atrial fibrillation at the KCNN3 gene. Since the KCNN3 gene encodes for a small conductance calcium-activated potassium channel, we hypothesized that overexpression of the SK3 channel increases susceptibility to cardiac arrhythmias. METHODS AND RESULTS: We characterized the cardiac electrophysiological phenotype of a mouse...

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Source

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Identifiers

PMID: 24296650
DOI: 10.1093/cvr/cvt269
PMCID: PMC3896252

Genes

KCNN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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