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Article

Atrial arrhythmogenicity in aged Scn5a+/DeltaKPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction.

Pflugers Archiv : European journal of physiology - 1 Aug 2010

Guzadhur Laila, Pearcey Sarah M, Duehmke Rudolf M, Jeevaratnam Kamalan, Hohmann Anja F, Zhang Yanmin, Grace Andrew A, Lei Ming, Huang Christopher L-H

Abstract excerpt

Recent studies have reported that human mutations in Nav1.5 predispose to early age onset atrial arrhythmia. The present experiments accordingly assess atrial arrhythmogenicity in aging Scn5a+/KPQ mice modeling long QT3 syndrome in relationship to cardiac Na(+) channel, Nav1.5, expression. Atrial electrophysiological properties in isolated Langendorff-perfused hearts from 3- and 12-month-old wild type (WT), and...

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Identifiers

PMID: 20552221
DOI: 10.1007/s00424-010-0851-z
PMCID: PMC2903684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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