Article
Scn2a deletion improves survival and brain-heart dynamics in the Kcna1-null mouse model of sudden unexpected death in epilepsy (SUDEP).
Human molecular genetics - 1 Jun 2017
Mishra Vikas, Karumuri Bharat K, Gautier Nicole M, Liu Rui, Hutson Timothy N, Vanhoof-Villalba Stephanie L, Vlachos Ioannis, Iasemidis Leonidas, Glasscock Edward
Abstract excerpt
People with epilepsy have greatly increased probability of premature mortality due to sudden unexpected death in epilepsy (SUDEP). Identifying which patients are most at risk of SUDEP is hindered by a complex genetic etiology, incomplete understanding of the underlying pathophysiology and lack of prognostic biomarkers. Here we evaluated heterozygous Scn2a gene deletion (Scn2a+/-) as a protective genetic modifier...
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