Supraventricular tachycardias, conduction disease, and cardiomyopathy in 3 families with the same rare variant in TNNI3K (p.Glu768Lys).

doi:10.1016/j.hrthm.2018.07.015

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Supraventricular tachycardias, conduction disease, and cardiomyopathy in 3 families with the same rare variant in TNNI3K (p.Glu768Lys).

Heart rhythm - 1 Jan 2019

Podliesna Svitlana, Delanne Julian, Miller Lindsey, Tester David J, Uzunyan Merujan, Yano Shoji, Klerk Mischa, Cannon Bryan C, Khongphatthanayothin Apichai, Laurent Gabriel, Bertaux Geraldine, Falcon-Eicher Sylvie, Wu Shengnan, Yen Hai-Yun, Gao Hanlin, Wilde Arthur A M, Faivre Laurence, Ackerman Michael J, Lodder Elisabeth M, Bezzina Connie R

Abstract excerpt

BACKGROUND: Rare genetic variants in TNNI3K encoding troponin-I interacting kinase have been linked to a distinct syndrome consisting primarily of supraventricular tachycardias and variably expressed conduction disturbance and dilated cardiomyopathy in 2 families. OBJECTIVE: The purpose of this study was to identify new genetic variants associated with inherited supraventricular tachycardias, cardiac conduction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiomyopathy, Dilated

Share to Cells, Cultured

Share to DNA

Share to Genetic Testing

Share to Heart Conduction System

Share to Magnetic Resonance Imaging, Cine

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed

Identifiers

PMID: 30010057
DOI: 10.1016/j.hrthm.2018.07.015

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Supraventricular tachycardias, conduction disease, and cardiomyopathy in 3 families with the same rare variant in TNNI3K (p.Glu768Lys).PMID 30010057Read ↗

TNNI3K mutation in familial syndrome of conduction system disease, atrial tachyarrhythmia and dilated cardiomyopathy.Semantic proximity Read ↗

Reduced kinase function in two ultra-rare TNNI3K variants in families with congenital junctional ectopic tachycardia.Semantic proximity Read ↗

Whole exome sequencing identifies the TNNI3K gene as a cause of familial conduction system disease and congenital junctional ectopic tachycardia.Semantic proximity Read ↗

The prevalent I686T human variant and loss-of-function mutations in the cardiomyocyte-specific kinase gene TNNI3K cause adverse contractility and concentric remodeling in mice.Semantic proximity Read ↗

Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TNNI3 c.235C > T variant.Semantic proximity Read ↗

Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes.Semantic proximity Read ↗

[Identification of variants in TNNI3 gene in two children with restrictive cardiomyopathy].Semantic proximity Read ↗

Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3Semantic proximity Read ↗

A Pathogenic Variant inALPK3Is Associated With an Autosomal Dominant Adult-onset Hypertrophic CardiomyopathySemantic proximity Read ↗

Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial FibrillationSemantic proximity Read ↗

Identification of rare variants in TNNI3 with atrial fibrillation in a Chinese GeneID population.Semantic proximity Read ↗

A Novel Missense Mutation in TNNI3K Causes Recessively Inherited Cardiac Conduction Disease in a Consanguineous Pakistani Family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.