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Article

Rescuing cardiac automaticity in L-type Cav1.3 channelopathies and beyond.

The Journal of physiology - 15 Oct 2016

Mesirca Pietro, Bidaud Isabelle, Mangoni Matteo E

Abstract excerpt

Pacemaker activity of the sino-atrial node generates the heart rate. Disease of the sinus node and impairment of atrioventricular conduction induce an excessively low ventricular rate (bradycardia), which cannot meet the needs of the organism. Bradycardia accounts for about half of the total workload of clinical cardiologists. The 'sick sinus' syndrome (SSS) is characterized by sinus bradycardia and periods of...

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Identifiers

PMID: 27374078
DOI: 10.1113/JP270678
PMCID: PMC5063940

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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