Article
Critical roles of a small conductance Ca²⁺-activated K⁺ channel (SK3) in the repolarization process of atrial myocytes.
Cardiovascular research - 1 Feb 2014
Zhang Xiao-Dong, Timofeyev Valeriy, Li Ning, Myers Richard E, Zhang Dai-Min, Singapuri Anil, Lau Victor C, Bond Chris T, Adelman John, Lieu Deborah K, Chiamvimonvat Nipavan
Abstract excerpt
AIMS: Small conductance Ca(2+)-activated K(+) channels (K(Ca)2 or SK channels) have been reported in excitable cells, where they aid in integrating changes in intracellular Ca(2+) (Ca(i)²⁺) with membrane potentials. We have recently reported the functional expression of SK channels in human and mouse cardiac myocytes. Additionally, we have found that the channel is highly expressed in atria compared with the...
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