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Article

Mechanisms by which SCN5A mutation N1325S causes cardiac arrhythmias and sudden death in vivo.

Cardiovascular research - 1 Feb 2004

Tian Xiao-Li, Yong Sandro L, Wan Xiaoping, Wu Ling, Chung Mina K, Tchou Patrick J, Rosenbaum David S, Van Wagoner David R, Kirsch Glenn E, Wang Qing

Abstract excerpt

OBJECTIVE: Mutations in the cardiac sodium channel gene SCN5A are responsible for type-3 long QT disease (LQT3). The genesis of cardiac arrhythmias in LQT3 is multifaceted, and the aim of this study was to further explore mechanisms by which SCN5A mutations lead to arrhythmogenesis in vivo. METHODS: We engineered selective cardiac expression of a long QT syndrome (LQTS) mutation (N1325S) in human SCN5A and...

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Identifiers

PMID: 14736542
DOI: 10.1016/j.cardiores.2003.11.007
PMCID: PMC1579709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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