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Integrating gene expression and epidemiological data for the discovery of genetic interactions associated with cancer risk.

Carcinogenesis - 1 Mar 2014

Bonifaci Núria, Colas Eva, Serra-Musach Jordi, Karbalai Nazanin, Brunet Joan, Gómez Antonio, Esteller Manel, Fernández-Taboada Enrique, Berenguer Antoni, Reventós Jaume, Müller-Myhsok Bertram, Amundadottir Laufey, Duell Eric J, Pujana Miquel Àngel

Abstract excerpt

Dozens of common genetic variants associated with cancer risk have been identified through genome-wide association studies (GWASs). However, these variants only explain a modest fraction of the heritability of disease. The missing heritability has been attributed to several factors, among them the existence of genetic interactions (G × G). Systematic screens for G × G in model organisms have revealed their...

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PMID: 24296589
DOI: 10.1093/carcin/bgt403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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