Article
Concordance of gene expression in human protein complexes reveals tissue specificity and pathology.
Nucleic acids research - 1 Oct 2013
Börnigen Daniela, Pers Tune H, Thorrez Lieven, Huttenhower Curtis, Moreau Yves, Brunak Søren
Abstract excerpt
Disease-causing variants in human genes usually lead to phenotypes specific to only a few tissues. Here, we present a method for predicting tissue specificity based on quantitative deregulation of protein complexes. The underlying assumption is that the degree of coordinated expression among proteins in a complex within a given tissue may pinpoint tissues that will be affected by a mutation in the complex and...
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