Article
Detecting High-Order Epistasis in Nonlinear Genotype-Phenotype Maps.
Genetics - 1 Mar 2017
Sailer Zachary R, Harms Michael J
Abstract excerpt
High-order epistasis has been observed in many genotype-phenotype maps. These multi-way interactions between mutations may be useful for dissecting complex traits and could have profound implications for evolution. Alternatively, they could be a statistical artifact. High-order epistasis models assume the effects of mutations should add, when they could in fact multiply or combine in some other nonlinear way. A...
Topics
- Bacteria
- Epistasis, Genetic
- Genotype
- Models, Genetic
- Phenotype
- Point Mutation
- Yeasts