Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Demethylation of cancer/testis antigens and CpG ODN stimulation enhance dendritic cell and cytotoxic T lymphocyte function in a mouse mammary model.

BioMed research international - 1 Jan 2013

Sun Jun-Zhong, Gao Lei, Gao Li, Wang Wei, Du Nan, Yang Juan, Wan Ling, Liu Fang, Wang Li-li, Yu Li

Abstract excerpt

BACKGROUND: Cancer/testis antigens (CTAs) are ideal targets for cancer immunotherapy in virtue of their restricted expression profile in normal tissues. However, CTA-targeted immunotherapy has been rather disappointing clinical setting for CTAs are downregulated by cytosine-phosphate-guanosine (CpG) methylation in their promoter regions, so that tumor cells have low immunogenicity. METHODS: We reinduced mouse CTA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dendritic Cells

Share to Granzymes

Share to Mammary Neoplasms, Experimental

Share to Oligodeoxyribonucleotides

Share to Perforin

Share to T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 24294600
DOI: 10.1155/2013/196894
PMCID: PMC3835908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Demethylation of cancer/testis antigens and CpG ODN stimulation enhance dendritic cell and cytotoxic T lymphocyte function in a mouse mammary model.PMID 24294600Read ↗

Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cellsSemantic proximity Read ↗

Characterization of a cancer/testis (CT) antigen gene family capable of eliciting humoral response in cancer patients.Semantic proximity Read ↗

Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated ImmunotherapySemantic proximity Read ↗

Epigenetic modulation of solid tumors as a novel approach for cancer immunotherapy.Semantic proximity Read ↗

Expression of cancer testis antigens in human BRCA-associated breast cancers: potential targets for immunoprevention?Semantic proximity Read ↗

MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A(∗)0201 alleles.Semantic proximity Read ↗

Enhanced immune response induced by P5 HER2/neu-derived peptide-pulsed dendritic cells as a preventive cancer vaccine.Semantic proximity Read ↗

Enhanced dendritic cell-based immunotherapy using low-dose cyclophosphamide and CD25-targeted antibody for transplanted Lewis lung carcinoma cells.Semantic proximity Read ↗

Glycyrrhiza uralensis polysaccharides as a DC-based Vaccine Adjuvant: Enhanced Immunotherapy Combined with PD-1 BlockadeSemantic proximity Read ↗

Glycyrrhiza uralensis polysaccharides as a Dendritic Cell-Based Vaccine Adjuvant: Enhanced Cancer Immunotherapy Combined with PD-1 BlockadeSemantic proximity Read ↗

CD4+ T cells inhibit the neu-specific CD8+ T-cell exhaustion during the priming phase of immune responses against breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.