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Article

Epigenetic modulation of solid tumors as a novel approach for cancer immunotherapy.

Seminars in oncology - 1 Oct 2005

Sigalotti Luca, Coral Sandra, Fratta Elisabetta, Lamaj Elda, Danielli Riccardo, Di Giacomo Anna Maria, Altomonte Maresa, Maio Michele

Abstract excerpt

Emerging evidence demonstrates that epigenetic events associated with tumor development and progression may impair immunogenicity and immune recognition of cancer cells, possibly favoring their escape also from vaccination-induced antitumor immune responses. In fact, DNA hypermethylation and/or histone deacetylation plays a critical role in the downregulation and/or silencing of several genes involved in the...

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Identifiers

PMID: 16210088
DOI: 10.1053/j.seminoncol.2005.07.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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