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Article

Enhanced dendritic cell-based immunotherapy using low-dose cyclophosphamide and CD25-targeted antibody for transplanted Lewis lung carcinoma cells.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Apr 2015

Son Cheol-Hun, Bae Jae-Ho, Lee Hong-Rae, Shin Dong-Yeok, Yang Kwangmo, Park You-Soo

Abstract excerpt

Regulatory T cells (Tregs) is one of the main obstacles to the success of cancer immunotherapy. The effect of dendritic cell (DC)-based immunotherapy can be attenuated by immune suppressive functions of Tregs. We used a CD25-targeted antibody and low-dose cyclophosphamide (CTX) as immunomodulators to increase the antitumor effect of intratumoral injection of immature DCs into the irradiated tumor cells (IR/iDC)....

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Identifiers

PMID: 25751500
DOI: 10.1097/CJI.0000000000000068

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