Article
CD4+ T cells inhibit the neu-specific CD8+ T-cell exhaustion during the priming phase of immune responses against breast cancer.
Breast cancer research and treatment - 1 Apr 2011
Kmieciak Maciej, Worschech Andrea, Nikizad Hooman, Gowda Madhu, Habibi Mehran, Depcrynski Amy, Wang Ena, Godder Kamar, Holt Shawn E, Marincola Francesco M, Manjili Masoud H
Abstract excerpt
Studies conducted in animal model of infectious diseases or H-Y antigen model suggest a crucial role for CD4+ T cells in providing help for CD8+ T-cell memory responses. This concept suggests that inclusion of T helper epitopes in vaccine formulation will result in improved CD8+ T-cell responses. Although this concept has been applied to cancer vaccine design, the role of CD4+ T cells in the memory...
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