Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells

19 Feb 2018

Abstract excerpt

Abstract In cancer cells, cancer/testis (CT) antigens become epigenetically derepressed through DNA demethylation and constitute attractive targets for cancer immunotherapy. Here we report that activated CD4+ T helper cells treated with a DNA-demethylating agent express a broad repertoire of endogenous CT antigens and can be used as antigen-presenting cells to generate autologous cytotoxic T lymphocytes (CTLs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29511178
DOI: 10.1038/s41467-018-03217-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cellsPMID 29511178Read ↗

Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated ImmunotherapySemantic proximity Read ↗

Epigenome-Driven Strategies for Personalized Cancer ImmunotherapySemantic proximity Read ↗

The Cancer Epigenome: Exploiting Its Vulnerabilities for Immunotherapy.Semantic proximity Read ↗

Epigenetic modulation of solid tumors as a novel approach for cancer immunotherapy.Semantic proximity Read ↗

HLA-mediated tumor escape mechanisms that may impair immunotherapy clinical outcomes via T-cell activationSemantic proximity Read ↗

Polyclonal expansion of functional tumor-reactive lymphocyte infiltrating glioblastoma for personalized cell therapySemantic proximity Read ↗

Combining DNA damaging therapeutics with immunotherapy: more haste, less speedSemantic proximity Read ↗

Epigenetic engineering for optimal chimeric antigen receptor T cell therapySemantic proximity Read ↗

Epigenetic modulation in cancer immunotherapySemantic proximity Read ↗

The Flipside of the Power of Engineered T Cells: Observed and Potential Toxicities of Genetically Modified T Cells as TherapySemantic proximity Read ↗

Combination of epigenetic regulation with gene therapy-mediated immune checkpoint blockade induces anti-tumour effects and immune response in vivoSemantic proximity Read ↗

Adoptive immunotherapy with genetically modified lymphocytes in allogeneic stem cell transplantationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.